Syria's President Bashar al-Assad and his wife Asma have tested positive for COVID-19 after showing minor symptoms, his office said on Monday.
The pair are in good health and would keep working in isolation at home, the statement said.
Syria has seen a sharp rise in infections since mid-February. Health and aid officials say it remains difficult to gauge the full size of the outbreak given the lack of testing facilities in a fragile health system devastated by a decade of war.
Assad joins a growing list of world leaders who have tested positive for COVID-19, alongside Britain's Boris Johnson, France's Emmanuel Macron and former U.S. President Donald Trump.
Health workers said the authorities underplayed the size of the outbreak for most of last year, when official figures remained low as hospitals were overwhelmed and death notices appeared in newspapers.
The government denied undercounting the figures and has acknowledged in the last two months the country could be on the verge of a major spike.
It has urged people to wear face masks, take sanitary measures and avoid crowded areas.
Israel said it carried out a warning strike against an extremist group that was preparing to attack Druze in Syria, following through on its pledge to protect the minority group as violence spread in Druze areas near Damascus on Wednesday.
Swarms of Russian drones attacked the Ukrainian cities of Kharkiv and Dnipro late on Tuesday, killing at least one person and injuring at least 46, officials said.
At least 14 people died in the eastern Indian city of Kolkata late on Tuesday when a fire blazed through a six-storey hotel in a congested neighbourhood, authorities said.
Spain and Portugal switched their power back on after the worst blackout in their history, though authorities offered little explanation for what had caused it or how they would prevent it from happening again.
The head of Israel's domestic intelligence agency, Ronen Bar, announced he will resign on June 15 amid pressure from Prime Minister Netanyahu and ongoing legal proceedings.
President Donald Trump touted what he called a series of major economic wins and forcefully attacked Democrats during a rally in Michigan on Tuesday to commemorate his first 100 days in office.
Canadian Prime Minister Mark Carney's Liberals retained power in the country's election on Monday, but fell short of the majority government he had wanted to help him negotiate tariffs with US President Donald Trump.