A passenger bus plunged 200 metres (650 feet) from a mountainous road in west Nepal before dawn on Monday, killing 19 people including three foreign nationals.
Among those killed were a British, Chinese and Indian citizen, police said. The bus was carrying 44 passengers.
A New Zealander and a Chinese national were among 25 injured when the bus heading for Kathmandu from the tourist town of Pokhara fell from the road at Behighat in Dhading district, 80 km (50 miles) west of the capital, the police statement added.
The injured are being treated at hospitals in Kathmandu.
The government said it had ordered an investigation.
One killed, five injured in Bahrain from Iran strikes
Qatar is not directly mediating between US and Iran, ministry spokesperson says
Germany, France in rare rebuke of Trump over Iran war
Philippine president declares energy emergency over Middle East conflict risks
New York's LaGuardia airport faces second day of delays, cancellations after collision
Iran sends missiles into Israel, dismisses Trump's talk of negotiations as 'fake news'
Lebanon declares Iranian envoy persona non grata, asks him to leave by Sunday
Iran denies talks with US after Trump postpones strikes on power grid
