According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Swiatek reaches her first final of season at Canadian Open
Iga Swiatek has rallied from a break down in the deciding set to beat Ukraine's Elina Svitolina 6-3 1-6 6-3 at the Canadian Open on Wednesday, securing her place in a final for the first time this season at the US Open tune-up event in Toronto.
PSG retain UEFA Super Cup with win over Aston Villa
Goals from Khvicha Kvaratskhelia and Desire Doue have helped Paris St Germain to retain the UEFA Super Cup with a 2-1 victory over Aston Villa on Wednesday.
Americans Shelton, Nakashima to meet in Canadian Open final
Defending champion Ben Shelton will face Brandon Nakashima for the Canadian Open title on Thursday after both Americans advanced in straight sets to the final of a key US Open warm-up event.
Dalic named UAE coach after leaving Croatia
Croatian manager Zlatko Dalic has been appointed coach of the UAE, the country's football association (UAEFA) said on Wednesday.
Messi doubts playing 'for much longer' after father's death
Lionel Messi said on Wednesday he is having doubts about continuing his career following the death of his father last week.
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Pinoy Expat Corner
What are the rules and laws in the UAE regarding car modifications that every car owner should know?
Pinoy Expat Corner
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Pinoy Expat Corner
What inspired them to choose running as their form of exercise despite their busy work schedules as OFWs?
