Roger Federer took one step closer to a fourth Miami Open crown after defeating Canadian teenager Denis Shapovalov.
"It was a tactical match by me... I'm happy I was able to play with variations," said the 37-year-old Swiss, who won 6-2 6-4.
"I enjoyed it. I think I played very well. I had to. Because I think when you let Denis play, he's got some serious power, and he gets rhythm going. He can really put you in uncomfortable situations."
Defending champion Isner also bested a Canadian teenager, 18-year-old qualifier Felix Auger-Aliassime, 7-6 (3), 7-6 (4).
Leclerc laps fastest for Ferrari in first US GP practice
Bayern coach Kompany hospitalised after collapsing during training session
Alexander Volkanovski's title defence headlines UFC 333 in Abu Dhabi
Juventus fight back to draw with Rennes as Leverkusen go top
South Africa level test series with big win over Australia
