Jason Roy and captain Joe Root both smashed centuries as the tourists easily reached their target of 361 with eight balls to spare in Barbados.
It was their highest ever run-chase in the format.
Chris Gayle's innings of 139 off 129 balls went in vain as the Windies' poor form in ODI cricket continued.
The second encounter of the five-match series will be played on Friday.
Hamilton fastest to complete Ferrari's US Grand Prix practice sweep
Lewis Hamilton was the fastest for Ferrari in the final practice session for the US Grand Prix on Saturday, after teammate Charles Leclerc led Friday's two sessions at the Circuit of the Americas in Austin.
Gabriel shines at both ends as Arsenal ease past Everton to go level with Man City
Gabriel Magalhaes has proved Arsenal's hero at both ends of the pitch on Saturday as the reigning champions beat Everton 2-0 to draw level with Manchester City at the Premier League summit.
Jackson double ends Man City's perfect run as Villa win
Aston Villa snapped Manchester City's perfect Premier League run with a 2-1 home victory on Saturday as Nicolas Jackson struck in each half to hand Enzo Maresca's men a damaging defeat.
Varma leads India fightback in four-wicket victory over New Zealand
India's middle-order batter Tilak Varma has hammered a half-century off 25 balls as India chased down a target of 181 with a ball to spare, taking a 2-0 lead in the five-match Twenty20 series with New Zealand on Saturday.
Holder Rybakina sets up Fernandez clash in Ningbo final
Defending Ningbo Open champion Elena Rybakina overcame Russian sixth seed Diana Shnaider 6-3 7-5 in the semi-final on Saturday to reach another title clash and remind rivals of her threat ahead of next month's WTA Finals.
Saksi Ang Langit
December Avenue
Bittersweet
Madison Beer
Lifetime (Reimagined)
Ben&Ben
Pinoy Expat Corner
In the fight against cancer, how important is having a strong support system—family, friends, and the community?
Pinoy Expat Corner
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Pinoy Expat Corner
What should beginners know before getting into off-roading? What type of vehicle is ideal for off-road adventures?
