Real Madrid suffered a 3-2 defeat at home against Shakhtar Donetsk in their Champions League Group B opener on Wednesday.
The Ukrainian side raced into a 3-0 lead in the first half with a strike from Brazilian midfielder Tete, an own goal from Madrid defender Raphael Varane and a fine goal from Israeli forward Manor Solomon.
Luka Modric and substitute Vinicius Jr score Madrid's consolation goals in the second half.
Inter Milan were held to a 2-2 draw by Borussia Monchengladbach in the other Group B encounter.
Elsewhere, in Group A, defending champions Bayern Munich crushed Atletico Madrid 4-0 with winger Kingsley Coman scoring a brace, while Salzburg and Lokomotiv played out a 2-2 draw.
In Group C, Manchester City beat Porto 3-1 and Olympiakos overcame Marseille 1-0.
Meanwhile, in Group D, Liverpool edged Ajax 1-0 and Italian side Atalanta thrashed Denmark's Midtjylland 4-0.
Dubai to spotlight future of sport at World Sports Summit
Safeguarding rules bar 15-year-old Sooryavanshi from Indian dressing room
Top contender Sabalenka faces fresh scrutiny at Wimbledon as mental scars linger
Munoz strike sends Colombia into World Cup Round of 32
Qatar's sports minister, Madibo visit Canada's injured Kone
