It follows reports that President Trump was outraged by comments made by Mulvaney during the Ukraine corruption saga.
The allegations of abuse of power over the Ukraine incident led to impeachment proceedings against President Trump.
Mulvaney's departure has been on the cards for the last few weeks.
Mr Mulvaney is to become US special envoy to Northern Ireland, while North Carolina lawmaker Mark Meadows has been appointed to take over his former position.
Trump says US military strike killed leader of Venezuela's Tren de Aragua gang
President Donald Trump on Friday said US forces carried out a strike that killed Hector Rusthenford Guerrero Flores, also known as Niño Guerrero, the leader of Venezuelan prison gang Tren de Aragua.
US and Iran signal a peace deal is close
The United States and Iran signalled on Friday that an agreement to end their war was close, with a senior US administration official saying a text was in place that both sides like.
Qatar rejects media report on energy production decisions
Qatar’s International Media Office has strongly denied allegations published by The Washington Post claiming that the country’s energy production decisions were coordinated with Iran or intended to influence regional developments.
Trump says Iran war deal close as Strait of Hormuz tensions linger
Hopes grew on Friday for peace between Iran and the US after President Donald Trump said a deal could be signed as soon as this weekend, even as Tehran said it had not made a final decision on a pact.
Victims' families mark Air India crash anniversary with prayers and tributes
Families of the 260 people killed when an Air India Boeing 787 crashed in Ahmedabad a year ago gathered on Friday for prayers and a candlelight tribute to mark the anniversary of the disaster.
Ebola outbreak spreads to crowded displacement camp in Congo
Two Ebola-related deaths have been confirmed in a displacement camp in eastern Congo, the UN refugee agency said, with aid workers warning the risk of the disease spreading quickly in crowded refugee sites was high and worrying.
Fire breaks out at New Zealand's Wellington airport, disrupting flights
A blaze broke out at Wellington Airport in the capital of New Zealand on Friday, forcing evacuations from the main terminal and flight diversions.
Ukraine and Russia trade overnight drone strikes, officials say
Ukraine and Russia exchanged overnight drone strikes into early Friday, with Ukraine targeting a major oil processing and petrochemical region while Russia attacked railway stations and electrical substations.
Pinoy Expat Corner
Why did they choose bowling as their hobby, and what makes it unique compared to other activities?
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Pinoy Expat Corner
What’s the difference between fishing here in the UAE compared to the Philippines?
