Liverpool suffered their first defeat in the Premier League this season, going down 3-0 at Watford.
All the goals came in the second-half with Ismaila Sarr scoring a double and Troy Deeney netting his side's third.
Jurgen Klopp's men missed the chance of setting a top-flight record of 19 straight victories and were five games away from equalling Arsenal's all-time best unbeaten run of 49 matches.
The win helped Watford move out of the relegation places.
West Ham also climbed out of the bottom three with a 3-1 win over Southampton, while Bournemouth are now in the drop zone after their 2-2 draw at home to Chelsea.
Elsewhere, Newcastle finished 0-0 with Burnley and Brighton lost 1-0 at home to Crystal Palace.
In Sunday's games, Tottenham host Wolves and Manchester United head to Everton.
Marchand sparkles on return to global stage with 200m medley world record
German biathlete Dahlmeier dies after mountaineering accident
Mbappe inherits Real Madrid's number 10 jersey after Modric exit
Top seeds Zverev, Gauff advance at Canadian Open
Man City re-sign goalkeeper Trafford from Burnley on five-year deal
