According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Antonelli wins in Japan to become youngest F1 leader
Mercedes driver Kimi Antonelli won the Japanese Grand Prix on Sunday to clinch his second straight Formula One victory and become the youngest-ever championship leader.
Mayweather says rematch with Pacquiao is exhibition, venue still to be decided
Floyd Mayweather's scheduled rematch with Manny Pacquiao will be an exhibition fight, with the venue for the bout yet to be nailed down, the former multi-weight world champion said on Saturday.
Magnitude wins $12million Dubai World Cup
American challenger 'Magnitude' won the Dubai World Cup on Saturday, taking the $12 million feature race at Meydan Racecourse.
Sabalenka beats Gauff in Miami final, completes 'Sunshine Double'
Defending champion Aryna Sabalenka has beaten hometown favourite Coco Gauff 6-2 4-6 6-3 in the Miami Open final on Saturday to join an exclusive club by completing the coveted 'Sunshine Double'.
Eight players leave England camp ahead of Japan friendly
England boss Thomas Tuchel will have no choice but to ring the changes ahead of Tuesday's friendly with Japan at Wembley Stadium after eight players left the camp on Saturday with a variety of health issues and injury concerns.
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Pinoy Expat Corner
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Pinoy Expat Corner
What does someone working on a yacht usually do? Are they often out at sea, and how long do they usually stay there?
