World number one Novak Djokovic has pulled out of the French Open ahead of his quarter-final match due to a knee injury.
The top seed and defending champion was scheduled to play Casper Ruud in the quarter-finals on Wednesday.
The Serb sustained the injury during his marathon fourth-round win over Francisco Cerundolo on Monday.
The withdrawal ended the Serb's quest for a record-extending 25th Grand Slam trophy and will result in him losing the world number one ranking to Italian Jannik Sinner later this month.
"Due to a torn medial meniscus in his right knee (discovered during an MRI scan), Djokovic, who was supposed to play Casper Ruud in the quarter-finals tomorrow, has been forced to withdraw from the Roland Garros tournament," organisers said.
Last year's runner-up Ruud will now advance to the semi-finals.
Djokovic said he had been carrying an injury for a couple of weeks and that the problem flared up when he slipped during his match against Cerundolo.

Jackson double ends Man City's perfect run as Villa win
Varma leads India fightback in four-wicket victory over New Zealand
Holder Rybakina sets up Fernandez clash in Ningbo final
Bayern boss Kompany stable but sidelined for weeks, says club director
Mumbai Indians promote Pollard to head coach, replacing Jayawardene
