Third seed Aryna Sabalenka crashed out of the French Open with a third-round defeat to Russian 31st seed Anastasia Pavlyuchenkova.
The Belarusian lost the encounter 4-6 6-2 0-6.
The latest result leaves the women's draw without its top three seeds at the claycourt Grand Slam.
After the exits of Ash Barty and Naomi Osaka, Sabalenka was the highest seed remaining this week in Paris but she failed to keep a leash on her unforced errors to lose to the experienced 29-year-old Russian.
Sabalenka got off to a rollicking start for a 3-0 lead but her unforced errors abruptly mounted and Pavlyuchenkova won six of the next seven games to bag the set.
The 23-year-old hammered a flurry of winners to take four games in a row to win the second set and level the match before Pavlyuchenkova went off the court for medical attention, returning with her left thigh heavily strapped.
The injury seemed to have made no difference to Pavlyuchenkova's game as she handed a bagel to her opponent in the decider to set up a meeting against either Victoria Azarenka of Belarus or American Madison Keys.
Women's top seed Aryna Sabalenka was knocked out in the fourth round of Wimbledon by an inspired Naomi Osaka on Sunday with the Japanese player blazing to a 6-2 7-6(2) win on Centre Court.
Novak Djokovic added another chapter to his Wimbledon legacy on Sunday as the Serb fought past Russian qualifier Roman Safiullin 7-6(6) 6-3 3-6 6-3 to earn a record 106th match victory at the All England Club and reach another quarter-final.
Ferrari's Charles Leclerc won a dramatic British Grand Prix under safety car conditions on Sunday as Mercedes's Kimi Antonelli failed to score for the second time in three races and saw his once-commanding Formula One lead slashed to 25 points.
Fourth seed Jessica Pegula's greater experience proved telling as she beat rising fellow American Iva Jovic 4-6 6-3 6-1 to equal her best Wimbledon run by reaching the quarter-finals for the second time on Sunday.
Kylian Mbappe converted a second-half penalty as France sweated through a suffocating Philadelphia furnace and wrestled their way out of a brutal scrap with Paraguay to snatch a 1-0 win on Saturday, setting up a World Cup quarter-final against Morocco.
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