According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
10-man US beat Bosnia 2-0 to reach World Cup round of 16
The United States reached the World Cup round of 16 with a 2-0 win over Bosnia on Wednesday, with Malik Tillman scoring from a free kick to see the 10-man co-hosts home after Folarin Balogun was sent off having opened the scoring in the first half.
Belgium stage stunning comeback to sink Senegal in extra time
Youri Tielemans struck a 125th-minute penalty as Belgium rallied from two goals down and defeated Senegal 3-2 after extra time in their World Cup last 32 clash in Seattle on Wednesday to keep alive their title hopes that had looked dead and buried.
Kane double rescues England in comeback win over DR Congo
Harry Kane scored twice in the final 15 minutes to see England through to the World Cup round of 16 as they left it late overcome a dogged Democratic Republic of Congo 2-1 on Wednesday.
Gauff survives Wimbledon scare, Krejcikova rallies past Andreeva
Coco Gauff managed to shrug off her Wimbledon gremlins in the nick of time to avoid another early exit on Wednesday.
England-India T20 abandoned because of rain
England and India were left frustrated as the opening game of their three-match T20 series was abandoned because of rain at the halfway stage.
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Pinoy Expat Corner
What inspired them to take photography seriously here in the UAE?
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Pinoy Expat Corner
Why did they choose bowling as their hobby, and what makes it unique compared to other activities?
