According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Shelton stops Tsitsipas, sets up Alcaraz showdown at US Open
Eighth seed Ben Shelton outshone Stefanos Tsitsipas under the US Open spotlight on Sunday, sealing a 6-2 6-3 6-4 victory to reach the quarter-finals and boost home hopes of a first American men's Grand Slam champion in more than two decades.
Pegula powers past Cirstea as Romanian bids farewell to US Open
American Jessica Pegula has clinched a resounding 6-3 6-4 win over Sorana Cirstea on Sunday to reach the US Open quarter-finals, as the Romanian player made her final Grand Slam appearance.
Alcaraz outguns Paul to reach US Open quarter-finals
Carlos Alcaraz beat American 20th seed Tommy Paul 6-4 6-3 6-4 in a high-voltage hit-fest on Sunday to reach the quarter-finals of the U.S. Open and remain firmly on track for back-to-back titles at Flushing Meadows.
Antonelli takes sensational home Italian GP win from back of grid
Formula One leader Kimi Antonelli won his home Italian Grand Prix after a sensational race from 19th to first on Sunday in a massive blow for Mercedes teammate and closest championship rival George Russell.
Arsenal pass Chelsea test in style with comeback win
Arsenal passed their biggest test so far in the defence of their Premier League title in style as they hit back from conceding inside two minutes to beat Chelsea 2-1 with captain Martin Odegaard scoring the winner on Sunday.
Dracula (Jennie Remix)
Tame Impala & Jennie
Pomada
1St.one
Crazy
Stell
Pinoy Expat Corner
Why did they choose mountain biking as their sport? What makes mountain biking different from regular road cycling?
Pinoy Expat Corner
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Pinoy Expat Corner
Why is it important for them to preserve Ilokano culture and traditions even while living far from the Philippines?
