Jason Roy and captain Joe Root both smashed centuries as the tourists easily reached their target of 361 with eight balls to spare in Barbados.
It was their highest ever run-chase in the format.
Chris Gayle's innings of 139 off 129 balls went in vain as the Windies' poor form in ODI cricket continued.
The second encounter of the five-match series will be played on Friday.
Man City make it three wins in a row, Palace earn first points
Manchester City made it three wins from three but were relieved to hear the final whistle as they beat promoted Coventry City 1-0 in the Premier League on Saturday.
Alpine's Gasly seizes first career F1 pole ahead of Russell at Monza
French Formula One driver Pierre Gasly upset the favourites to grab a stunning career-first pole position with Renault-owned Alpine at the Italian Grand Prix on Saturday.
Springboks go 2-1 up in series after edging New Zealand
South Africa edged another ferocious and bruising clash against New Zealand to win the third test 29-24 on Saturday and go 2-1 up in the four-test series dubbed "Rugby's Greatest Rivalry".
Pogacar ends 2026 season early after Vuelta crash
Five-time Tour de France champion Tadej Pogacar has ended his season early to focus on recovery after last weekend's crash during Vuelta a Espana left him with injuries that required surgery, his team UAE Team Emirates-XRG said on Saturday.
Unstoppable Alcaraz dismantles Wu to reach US Open fourth round
Defending champion Carlos Alcaraz underlined his status as the man to beat at the US Open with a ruthless 6-3 6-4 6-1 victory over China's Wu Yibing on Friday as he reached the fourth round and continued his bid for a third title at Flushing Meadows.
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Pinoy Expat Corner
Why is it important for them to preserve Ilokano culture and traditions even while living far from the Philippines?
Pinoy Expat Corner
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Pinoy Expat Corner
What is their mission and vision for Filipinas in Sharjah and across the other emirates?
