Fifth-seeded Hubert Hurkacz has triumphed over fourth-seed Jannik Sinner 6-3 6-3 in the day's second quarter-final on centre court.
Earlier, second seed Andrey Rublev progressed beating Mackenzie McDonald 6-2 3-6 1-6.
The second semi-final places will go to the winners of the final two quarter-final matches, the first between top seed and world number one Novak Djokovic and qualifier Jiri Vesely, followed by Ricardas Berankis and sixth seed Denis Shapovalov.
Zverev brushes aside Darderi to reach US Open quarter-finals
Alexander Zverev has put a slow start to his US Open campaign further behind him as the top-seeded German defeated Italian Luciano Darderi 6-2 6-2 7-6(3) on Monday and moved into the quarter-finals.
Gauff downs fellow American Jovic to reach US Open last eight
Fourth seed Coco Gauff has stayed on course for a third Grand Slam title after reaching the US Open quarter-finals with a 6-1 6-4 win over fellow American Iva Jovic at Arthur Ashe Stadium on Monday.
Liam Lawson to replace injured Isack Hadjar again in Madrid
Liam Lawson will race alongside Red Bull superstar Max Verstappen for this weekend's Spanish Grand Prix with Isack Hadjar still sidelined by a wrist injury.
Rybakina thumps Osaka to reach US Open quarters, close in on top ranking
Elena Rybakina has cleared another big hurdle in her bid to win a third Grand Slam title by outclassing former US Open champion Naomi Osaka 6-1 6-4 on Monday to reach the quarter-finals at Flushing Meadows.
Zheng stuns Swiatek at US Open as Andreeva extends winning run
Chinese qualifier Zheng Qinwen produced another spectacular fight back to upset six-times major winner Iga Swiatek 7-5 6-3 in the US Open on Monday, recovering from 0-5 down in the opening set to reach the quarter-finals.
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Pinoy Expat Corner
Why did they choose mountain biking as their sport? What makes mountain biking different from regular road cycling?
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Pinoy Expat Corner
Why is it important for them to preserve Ilokano culture and traditions even while living far from the Philippines?
