Britain's defending Olympic champion Andy Murray pulled out of the Tokyo 2020 men's singles tournament on Sunday ahead of his first-round match.
The 34-year-old, who had been due to play Canada's Felix Auger-Aliassime, was sidelined by a thigh strain.
Murray has been replaced in the draw by Australian Max Purcell.
The Scot will continue to compete in the men's doubles tournament with Joe Salisbury, Team GB said, the pair having won their opening match on Saturday.
"I am really disappointed at having to withdraw but the medical staff have advised me against playing in both events," a statement from Murray read.
"I have made the difficult decision to withdraw from the singles and focus on playing doubles with Joe."
Murray won Olympic gold on Wimbledon's Centre Court at the London 2012 Games, and defended his title in Rio.
He underwent hip surgery in 2018 and 2019, and missed the Australian Open at the start of this year after contracting COVID-19.
Defending champion Carlos Alcaraz underlined his status as the man to beat at the US Open with a ruthless 6-3 6-4 6-1 victory over China's Wu Yibing on Friday as he reached the fourth round and continued his bid for a third title at Flushing Meadows.
UAE President His Highness Sheikh Mohamed bin Zayed Al Nahyan held a special meeting for the UAE youth handball team and its staff to honour them for qualifying for the 2027 IHF Men's Junior World Championship.
Two-time defending champion Aryna Sabalenka continued her imposing run at the US Open with a composed 6-3 6-4 victory over Kamilla Rakhimova in the third round on Friday, extending her bid for a fifth Grand Slam title.
The reigning T20 world champions India will play Japan for the first time in an international match when the teams meet at the Sano International Cricket Ground in Tochigi on September 22, the two cricket boards said on Friday.
Alexander Zverev survived another almighty scare at the US Open as the top seed overcame Frenchman Quentin Halys 6-4 4-6 7-6(3) 6-7(3) 6-3 on Thursday to secure a place in the third round of the Grand Slam.
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