It follows reports that President Trump was outraged by comments made by Mulvaney during the Ukraine corruption saga.
The allegations of abuse of power over the Ukraine incident led to impeachment proceedings against President Trump.
Mulvaney's departure has been on the cards for the last few weeks.
Mr Mulvaney is to become US special envoy to Northern Ireland, while North Carolina lawmaker Mark Meadows has been appointed to take over his former position.
Kuwait air defences deal with Iranian missile, drone attacks
The Kuwaiti Armed Forces have announced its air defence systems are actively intercepting Iranian missile and drone attacks early on Thursday.
Two Palestinian teens killed in West Bank raid by Israeli settlers, army
Two Palestinian teenagers have been killed on Wednesday in an attack by Israeli settler fighters and army troops on their village in the occupied West Bank, local officials and the Palestinian health ministry said.
Chinese students marooned in floods unleashed by Typhoon Saudel's rains
China has warned of flash floods in the southeastern province of Fujian while heavy rain trapped teachers and students in a compound in eastern Zhejiang as storms from Typhoon Saudel lashed several regions, state media said on Thursday.
US and Iran exchange attacks as lull in war appears over
The US and Iran found themselves back on a war footing on Wednesday after the most significant exchange of fire in weeks, with Washington threatening more devastating strikes.
Malta court clears businessman over murder of investigative journalist
Maltese businessman Yorgen Fenech, who was accused of commissioning the murder of investigative journalist Daphne Caruana Galizia, was acquitted on Wednesday at the end of a two-month trial.
Kuwait confirms no injuries after Iranian drone hits residential complex
Kuwait’s fire service said crews extinguished a blaze at a residential complex in the capital early on Wednesday after it was struck by an Iranian drone, causing no injuries.
Nepal flood rescue hopes dim as China restores access to Tibet disaster zone
Hopes of finding more survivors among thousands still missing in Nepal were fading on Wednesday, but authorities believed that dozens of workers trapped in the tunnels of hydropower projects hit by the Himalayan catastrophe could still be alive.
At least 21 die in bus accident in Egypt's South Sinai, ministry says
At least 21 people were killed in a bus accident on Egypt's Dahab-Nuweibaa road in South Sinai on Wednesday, the health ministry said.
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Pinoy Expat Corner
Why is it important for them to preserve Ilokano culture and traditions even while living far from the Philippines?
Pinoy Expat Corner
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Pinoy Expat Corner
What is their mission and vision for Filipinas in Sharjah and across the other emirates?
