The United States has evacuated more than 300 citizens out of Wuhan.
The two flights left the Chinese city on Tuesday after the passengers were screened.
In a statement, the US State Department said the passengers will be subject to "Centres for Disease Control (CDC) screening, health observation, and monitoring requirements" upon arrival at one of two California military bases.
Authorities added that more flights for US citizens in Wuhan could be scheduled for Thursday.
It comes as China criticised the US of spreading fear over the coronavirus outbreak.
St. Petersburg region port, oil terminal hit in Ukrainian drone attack
Trump extols America, rails at communism in US 250th celebration
Zelenskyy denies Russian capture of key eastern city Kostiantynivka
Keiko Fujimori declared winner of Peru presidential race
Ukrainian rescuers clear rubble as Kyiv mourns 30 killed in Russian attack
Monaco blast suspect is a Ukrainian woman who fled to Germany
Clinical trials begin for two potential Ebola treatments
India issues notice to Telegram, Signal on concerns over usernames, source says
