US President Donald Trump clashed with his Democratic challenger, former Vice President Joe Biden, in Cleveland, Ohio, ahead of the November 3 election.
Chris Wallace was moderating the first of three presidential debates on Tuesday, as reports noted more than 70 interruptions were made between the two candidates over 90 minutes.
At one point the Fox News anchor made an appeal to Trump during the debate saying: "The country would be better served if we allowed both people to speak with fewer interruptions."
COVID-19 was the longest segment with around 20 minutes spent on the pandemic's economic impact, vaccines, masks and the president's general handling of the crisis.
Other topics raised included race and violence, election integrity and climate change.
St. Petersburg region port, oil terminal hit in Ukrainian drone attack
Thousands protest in Germany as far-right AfD sets sights on power
Trump extols America, rails at communism in US 250th celebration
Zelenskyy denies Russian capture of key eastern city Kostiantynivka
Keiko Fujimori declared winner of Peru presidential race
Ukrainian rescuers clear rubble as Kyiv mourns 30 killed in Russian attack
Monaco blast suspect is a Ukrainian woman who fled to Germany
Clinical trials begin for two potential Ebola treatments
