Bahrain will suspend dine-in services at restaurants and cafes and move public and private schools to remote learning for three weeks to contain the spread of the coronavirus, the health ministry said.
It said it had detected a new variant of coronavirus in a number of cases, without specifying which kind.
The new lockdown measures will come into effect on Sunday.
There has been an uptick in coronavirus cases in the Gulf kingdom since December. The country registered 459 new cases on Wednesday, adding to a total of nearly 100,000 since the start of the pandemic, with 370 deaths.
The small island state has the third highest rate of vaccinations per capita in the world so far, according to the Our World in Data website, which is run by an Oxford University research programme.
Bahrain offers its citizens either the Pfizer/BioNTech vaccine or one manufactured by Chinese state-backed pharmaceutical giant Sinopharm free of charge.
The kingdom also approved the AstraZeneca COVID-19 vaccine on Monday for emergency use.
President Donald Trump's swift rejection of Iran's response to a US peace proposal sent oil prices surging on Monday amid concerns the 10-week-old conflict will drag on, keeping shipping through the Strait of Hormuz paralysed.
The man accused of attempting to assassinate US President Donald Trump at a White House reporters' gala last month pleaded not guilty to all charges on Monday.
Prime Minister Keir Starmer promised to be bolder to turn around Britain's fortunes, making an impassioned plea to both his Labour Party and voters on Monday to stick with him and avoid a leadership contest he said would only bring chaos.
The evacuation of passengers from a Dutch-flagged luxury cruise ship hit by a deadly hantavirus outbreak will be completed on Monday with flights from Australia and the Netherlands, Spain's health minister has said.
Lawmakers in the Philippines are set to vote on Monday on whether to impeach Vice President Sara Duterte, in what could create a major hurdle for her bid to run for the presidency in 2028.
Six bodies were found on Sunday in a train boxcar in Laredo, Texas, according to police, with an investigation ongoing to determine the cause of death.
A tyre of a Turkish Airlines plane caught fire after it landed on Monday in Nepal's capital of Kathmandu, authorities said, forcing the closure of the airport for an hour.
Thailand's influential former Prime Minister Thaksin Shinawatra has been released from prison on Monday, after about eight months behind bars following a court ruling that deemed he had wrongfully stayed in hospital to avoid jail time.
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