Half of the passengers in a bus carrying 43 Indians died on Friday when the vehicle plunged into a rain-swollen river in neighbouring Nepal.
A total of 21 people died and 22 were injured, Shailendra Thapa, a spokesperson for the armed police said, adding that all 41 passengers and two crew were Indian and headed to capital Kathmandu from the tourist city of Pokhara when the accident occurred.
Roads in the mountainous region can challenge drivers as they are often narrow and treacherous, making it tough to manoeuvre large vehicles around hairpin curves.
Rescuers pulled 22 people from the rain-swollen waters of the Marsyangdi river in the Tanahun district, about 118 km (73 miles) from Kathmandu, of which 12 were seriously injured and airlifted to the capital.
Police and army teams climbed down long metal ladders to reach the river, using ropes to pull out the injured and dead.
Exhausted women and children lay amid debris scattered on the banks of the fast-flowing river as rescuers hauled a nearly fainting child out of danger, video images showed.
The Indian state of Uttar Pradesh, where passengers had boarded the bus, is sending an official to coordinate rescue efforts, news agency ANI said.

Chinese national rescued from Nepal tunnel 10 days after flash flood
US envoys Witkoff, Kushner arrive in Moscow for talks on peace in Ukraine
One dead, 11 people missing after mudslide in China's Jiangxi province
Philippine VP Duterte posts bail after arrest order for alleged grave threats
Lindsay Clancy trial over killing her children ends in mistrial
Israel says it strikes southern Lebanon after Hezbollah drone launch
Sydney sweats in spring hot spell, faces 'extreme' bushfire risk
Nine days after disaster, two pulled alive from Nepal hydropower tunnel
